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Incidence and trends of non-fatal overdoses among people with and without HIV : a population-based cohort study in British Columbia, Canada (2012–2020)

Kooij, Katherine W. ; Marziali, Megan; Budu, Michael; Trigg, Jason; Ye, Monica; Zhang, Wendy; McLinden, Taylor; Emerson, Scott D.; Salters, Kate; Martins, Silvia S.; Montaner, Julio; Hogg, Robert S.

2025-11-24

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Our study investigated the age-adjusted incidence rates of non-fatal overdoses by HIV status and sex, and examined trends over time in British Columbia, Canada. We used data from the Comparative Outcomes and Service Utilization Trends study, a population-based cohort study that includes clinical and administrative health data on virtually all people with HIV (PWH) and a 10% random sample of people without HIV in the province. We observed a significantly higher non-fatal overdose rate among PWH compared to people without HIV. The rate was highest among females with HIV. These findings underline the need for policies and programmes oriented towards PWH to mitigate overdoses, especially for females.