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Slow-Release Oral Morphine vs Methadone for Opioid Use Disorder in the Fentanyl Era
Eugenia Socias, M.; Lei, Jingxin; Zhou, Vivienne; Anand, Rohan; Cui, Zishan; Penta, Stephanie; Larochelle, Marc; Lodi, Sara; Fairbairn, Nadia
2026-03-24
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Link to PubMed Central (PMC)
https://pmc.ncbi.nlm.nih.gov/articles/PMC13014207/Link to JAMA Network
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2846926Access issues?
Description
What are the comparative discontinuation rates and mortality risks of slow-release oral morphine (SROM) vs methadone for the treatment of opioid use disorder (OUD) in the fentanyl era? In this comparative effectiveness study that included 4059 person-trials in British Columbia, Canada, SROM for OUD was associated with slightly higher treatment discontinuation risk than methadone but similar mortality risk. This suggests that either medication may be appropriate alongside measures to support retention.