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Examining the association between fentanyl use and perceived adequacy of methadone dose : A retrospective cohort study
Young, Samantha; Raboud, Janet; Dodd, Zoë; DeBeck, Kora; Milloy, MJ; Wilson, Dean; Hayashi, Kanna; Bayoumi, Ahmed M.; Fairbairn, Nadia
2025-02-01
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https://pmc.ncbi.nlm.nih.gov/articles/PMC12327950/Access issues?
Description
People exposed to fentanyl may report that the dose of methadone in the commonly accepted therapeutic range feels too low. We examined self-reported methadone dose adequacy. We found that exposure to non-fentanyl opioids while on methadone was not associated with feeling the dose was too low compared with individuals exposed to fentanyl. Our findings support adequate titration of methadone for individuals with continued exposure to unregulated opioids including fentanyl.